Peyronie disease is a buildup of scar tissue in the penis. It causes the penis to curve during erections. This causes pain.
It is treated with medicine. Some people may need surgery. Natural therapies have been used to ease pain. They should not be used in place of standard care.
These herbs and supplements may be effective:
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse. For example, PABA (para-aminobenzoic acid) should not be taken by people taking antibiotics, people with ulcerative colitis, or people that are about to have surgery.
Herbs and Supplements
A1. Hasche-Klünder R. [Treatment of Peyronie’s disease with para-aminobenzoacidic potassium (POTOBA) (author’s transl)]. Urologgee A. 1978;17(4):224-227.
A2. Safarinejad MR. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie’s disease: a double-blind, placebo-controlled randomized trial. Int J Impot Res. 2010;22(5):298-309.
A3. Paulis G, Brancato T, et al. Efficacy of vitamin E in the conservative treatment of Peyronie’s disease: legend or reality? A controlled study of 70 cases. Andrology. 2013;1(1):120-128.
A4. Paulis G, Cavallini G, et al. Long-term multimodal therapy (verapamil associated with propolis, blueberry, vitamin E and local diclofenac) on patients with Peyronie's disease (chronic inflammation of the tunica albuginea). Results of a controlled study. Inflamm Allergy Drug Targets. 2013 Dec;12(6):403-409.
A5. Prieto Castro RM, Leva Vallejo ME, et al. Combined treatment with vitamin E and colchicine in the early stages of Peyronie's disease. BJU Int. 2003 Apr;91(6):522-524.
Shock wave therapy
B1. Hauck EW, Mueller UO, et al. Extracorporeal shock wave therapy for Peyronie’s disease: exploratory meta-analysis of clinical trials. J Urol. 2004;171(2):740-745.
Last reviewed May 2019 by EBSCO NAT Review Board Eric Hurwitz, DC Last Updated: 6/12/2020